| 货号 | 1744/10 |
| 别名 | (2E)-3-[(4-Methylphenyl)sulfonyl]-2 |
| 供应商 | Tocris |
| 生物活性 | E2 ubiquitin (Ub) conjugating enzyme inhibitor. Inhibits the conjugation of Ub to a range of E2 enzymes. Inhibits E2 enzyme mediated IκBα phosphorylation and indirectly decreases NF-κb activity. Also reversibly activates MAPK signaling. Induces apoptosis of leukemic T cell and B-cell lymphoma cell lines. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 207.25 |
| 分子式 | C10H9NO2S |
| 可溶性/溶解性 | Soluble to 25 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 19542-67-7 |
| 参考文献 | Stricksonet al (2013) The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. Biochem.J. 451 427. PMID: 23441730. Moriet al (2002) Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells. Blood 100 1828. PMID: 12176906. Pierceet al (1997) Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J.Biol.Chem. 272 21096. PMID: 9261113. |