货号 | 1428/100U |
供应商 | Tocris |
生物活性 | Human form of the predominant amyloid β-peptide found in the brains of patients with Alzheimer's disease. Downregulates bcl-2 and increases the levels of bax. Neurotoxic. Control peptide (Cat. No. 3391) also available. |
运输条件 | Blue Ice |
存放说明 | -20℃ |
计算分子量 | 4514.08 |
分子式 | C203H311N55O |
可溶性/溶解性 | Soluble to 1 mg/ml in 50mM Tris buffer |
序列号 | DAEFRHDSGYEVHHQKLVFFAEDVGSNKGA |
参考文献 | Paradiset al (1996) Amyloid beta peptide of Alzheimer's disease downregulates bcl-2 and upregulates bax expression in human neurons. J.Neurosci. 16 7533. PMID: 8922409. Van Nostrandet al (1996) Amyloid β-protein induces the cerebrovascular cellular pathology of Alzheimer's disease and related disorders. Ann.N.Y.Acad.Sci. 777 297. PMID: 8624102. Glenner and Wong (1984) Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem.Biophys.Res.Commun. 120 885. PMID: 6375662. |