| 货号 | 1234/10 |
| 别名 | 5-(Methylamino)-2-[[2R,3R,6S,8S,9R, |
| 供应商 | Tocris |
| 生物活性 | Calcium ionophore that induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Promotes intracelllular ROS generation and platelet particle formation (fragmentation) in vitroandin vivo. Can be used to induce autophagy in mammalian cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 523.63 |
| 分子式 | C29H37N3O6 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 52665-69-7 |
| 参考文献 | Sakanashiet al (2009) Zn2+, derived from cell preparation, partly attenuates Ca2+-dependent cell death induced by A23187, calcium ionophore, in rat thymocytes. Toxicol.In Vitro 23 338. PMID: 19124067. Dinget al (2007) Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J.Biol.Chem. 282 4702. PMID: 17135238. Kajitaniet al (2007) Mechanism of A23187-induced apoptosis in HL-60 cells: dependency on mitochondrial permeability transition but not NADPH oxidase. Biosci.Biotechnol.Bichem. 71 2701. PMID: 7535265. Nardiet al (2007) Platelet particle formation by anti-GPIIIa49-66 Ab, Ca2+ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexamethasone blockade of platelet phospholipase A2, 12-lipoxygenase, and NADPH oxidase. Blood 110 1989. PMID: 17545506. |