| 货号 | 0282/10 |
| 别名 | (S)-(-)-3-Amino-1-hydroxypyrrolidin |
| 供应商 | Tocris |
| 生物活性 | Possesses potent sedative and ataxic action, probably through disruption of striatal dopaminergic mechanisms. R-enantiomer (Cat. No. 0281) also available. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 116.12 |
| 分子式 | C4H8N2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 111821-58-0 |
| 参考文献 | Grobaskiet al (1997) Responses of rat substantia nigra dopamine-containing neurones to (-)-HA-966 in vitro. Br.J.Pharmacol. 120 575. PMID: 9051293. Shepard and Lehmann (1992) (±)-1-Hydroxy-3-aminopyrrolidone-2 (HA-966) inhibits the activity of substantia nigra dopamine neurons through a non-N-methyl-D-aspartate receptor mediated mechanism. J.Pharmacol.Exp.Ther. 261 387. PMID: 1578355. Singhet al (1990) Enantiomers of HA-966 (3-amino-1-hydroxypyrrolidin-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA966 is a potent γ-butyrolactone-like sedative. Proc.Natl.Acad.Sci.U.S.A. 87 347. PMID: 2153294. |