| 货号 | 0495/25 |
| 别名 | trans-(±)-3,4-Dichloro-N-methyl-N-[2 |
| 供应商 | Tocris |
| 生物活性 | Selectiveκ-opioid agonist. At higher concentrations blocks Na+ channels. Separate isomers (+)-U-50488 and (-)-U-50488 also available (Cat. Nos. 0471 and 0496 respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 405.79 |
| 分子式 | C19H26Cl2N2O.HCl |
| 可溶性/溶解性 | Soluble to 25 mM in water |
| CAS号 | 67198-13-4 |
| 参考文献 | Suet al (1998) Blockade of the development of morphine tolerance by U-50,488, an AVP antagonist or MK 801 in the rat hippocampal slice. Br.J.Pharmacol. 123 625. PMID: 9517380. Pao-Luh Taoet al (1994) U-50,488 blocks the development of morphine tolerance and dependence at a very low dose in guinea pigs. Eur.J.Pharmacol. 256 281. PMID: 8045272. Suarez-Roca and Maixner (1993) Activation of kappa opioid receptors by U-50488H and morphine enhances the release of substance P from rat trigeminal nucleus slices. J.Pharmacol.Exp.Ther. 264 648. PMID: 7679733. Pugsleyet al (1992) Cardiovascular actions of the κ-agonist, U-50-488H, in the absence and presence of opioid receptor blockade. Br.J.Pharmacol. 105 521. PMID: 1320979. |