| 货号 | 19354-5mg |
| 描述 | Enkephalin convertase, also known as carboxypeptidase E, removes C-terminal residues during the processing of propeptides, including enkephalin and proinsulin. 2-Guanidinoethylmercaptosuccinic acid (GEMSA) is a potent inhibitor of enkephalin convertase (Ki = 8.8 nM) that is functional in vivo.1,2 It is a peptidomimetic inhibitor, occupying the specificity pocket of the enzyme.3 GEMSA can also inhibit other carboxypeptidases, including thrombin-activatable fibrinolysis inhibitor.4,5 |
| 别名 | GEMSA; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Przewlocka, B.,Dziedzicka, M.,Silberring, J., et al. Analgesic and convulsant effects of guanidinoethylmercaptosuccinic acid (GEMSA)--a potent enkephalin convertase inhibitor. Neuropeptides 8(4), 359-365 (1986). 2.Bommer, M.,Nikolarakis, K.,Noble, E.P., et al. In vivo modulation of rat hypothalamic opioid peptide content by intracerebroventricular injection of guanidinoethylmercaptosuccinic acid (GEMSA): Possible physiological role of enkephalin convertase. Brain Research 492(1-2), 305-313 (1989). 3.Aloy, P.,Companys, V.,Vendrell, J., et al. The crystal structure of the inhibitor-complexed carboxypeptidase D domain II and the modeling of regulatory carboxypeptidases. The Journal of Biological Chemisty 276(19), 16177-16184 (2001). 4.Bajzar, L.,Manuel, R., and Nesheim, M.E. Purification and characterization of TAFI, a thrombin-activable fibrinolysis inhibitor. The Journal of Biological Chemisty 270(24), 14477-14484 (1995). 5.Ore, F.D.,Ajandouz, E.H.,Giardina, T., et al. The membrane-bound basic carboxypeptidase from hog intestinal mucosa. Biochim.Biophys.Acta. 1421(2), 234-248 (2016). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥98% |
| 计算分子量 | 235.3 |
| 分子式 | C7H13N3O4S |
| CAS号 | 77482-44-1 |
| 稳定性 | ≥ 1 year |
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