| 货号 | 2816/1 |
| 别名 | (4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihy |
| 供应商 | Tocris |
| 生物活性 | Steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Inhibits endothelial cells (HUVEC) sprouting in vitro(IC50 = 12 nM) and in vivo. Prevents NF-κB activation by inhibiting activation of IKKβ. Also inhibits chymotrypsin-like activity of the 20S proteasome. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 470.6 |
| 分子式 | C28H38O6 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO and to 5 mM in ethanol |
| CAS号 | 5119-48-2 |
| 参考文献 | Kailehet al (2007) Withaferin A strongly elicits IkB kinase β hyperphosphorylation concomitant with potent inhibition of its kinase activity. J.Biol.Chem. 282 4253. PMID: 17150968. Yanget al (2007) The tumor proteasome is a primary target for the natural anticancer compound withaferin A isolated from "Indian Winter Cherry". Mol.Pharmacol. 71 426. PMID: 17093135. Mohanet al (2004) Withaferin A is a potent inhibitor of angiogenesis. Angiogenesis 7 115. PMID: 15516832. |