| 货号 | 3048/1 |
| 别名 | (2E)-3-[(4S,7R,7aR)-2,4,5,6,7,7a-He |
| 供应商 | Tocris |
| 生物活性 | Positive allosteric modulator of GABAA receptors that displays preference for receptors containing β2orβ3 subunits. Directly activates the receptor and blocks the channel at high concentrations. Displays sedative, anticonvulsant and anxiolytic activity in vivo. Also acts as a partial |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 234.33 |
| 分子式 | C15H22O2 |
| 可溶性/溶解性 | Soluble in ethanol |
| CAS号 | 3569-10-6 |
| 参考文献 | Khomet al (2016) Analysis of β-subunit-dependent GABAA receptor modulation and behavioral effects of valerenic acid derivatives. J.Pharmacol.Exp.Ther. 357 580. PMID: 27190170. Benkeet al (2008) GABAA receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacology 56 174. PMID: 18602406. Khomet al (2007) Valerenic acid potentiates and inhibits GABAA receptors: molecular mechanism and subunit specificity. Neuropharmacol. 53 178. PMID: 17585957. Dietzet al (2005) Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. Brain Res.Mol.Brain Res. 138 191. PMID: 15921820. |