| 货号 | 5069/50 |
| 别名 | 2-Cyano-3-hydroxy-N-[4-(trifluorome |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of dihydroorotate dehydrogenase (Kd = 12 nM; Ki = 179 nM). Inhibits proliferation of mitogen- or cytokine-stimulated lymphoid cells in vitro by inhibiting cell cycle progression from G1 to S. Imunosuppressive agent. Active metabolite of leflunomide (Cat. No. 2228). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 270.21 |
| 分子式 | C12H9F3N2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Iglesias-Bregnaet al (2013) Effects of prophylactic and therapeutic teriflunomide in transcranial magnetic stimulation-induced motor-evoked potentials in the dark agouti rat model of experimental autoimmune encephalomyelitis. J.Pharmacol.Exp.Ther. 347 203. PMID: 23892570. Daviset al (1996) The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase. Biochemistry 35 1270. PMID: 8573583. Williamsonet al (1995) Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound. J.Biol.Chem. 270 22467. PMID: 7673235. |