| 货号 | 2504/50 |
| 别名 | 6-(2,5-Dichlorophenyl)-1,3,5-triazi |
| 供应商 | Tocris |
| 生物活性 | Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitroandin vivoangiogenesis. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 372.18 |
| 分子式 | C9H7Cl2N5.C4H4O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 84504-69-8 |
| 参考文献 | Kyoiet al (2004) Phosphodiesterase type IV inhibitors prevent ischemia-reperfusion-induced gastric injury in rats. J.Pharmacol.Sci. 95 321. PMID: 15272207. Kyoiet al (2004) Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils. Life Sci. 76 71. PMID: 15501481. Nozakiet al (2004) Inhibition of breast cancer regrowth and pulmonary metastasis in nude mice by anti-gastric ulcer agent, irsogladine. Breast Cancer Res.Treat. 83 195. PMID: 14758089. |