| 货号 | 3406/1 |
| 供应商 | Tocris |
| 生物活性 | NMDA receptor partial agonist that acts at the glycine site. Simultaneously acts as a promoter of the induction of long-term potentiation (LTP) and as a suppressor of long-term depression (LTD). Exhibits nootropic, neuroprotective and antinociceptive activity, and enhances learning, memory and cognition in vivo. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 413.47 |
| 分子式 | C18H31N5O6 |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| CAS号 | 117928-94-6 |
| 序列号 | TPPT (Modifications: Thr-4 = C-terminal amide) |
| 参考文献 | Burgdorfet al (2009) The N-methyl-D-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats. Neurobiol.Aging 32 698. PMID: 19446371. Woodet al (2008) Antinociceptive action of GLYX-13: a N-methyl-D-aspartate receptor glycine site partial agonist. Neuroreport. 19 1059. PMID: 18580579. Zhanget al (2008) A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral-CA1 synapses in hippocampus. 55 1238. PMID: 18796308. Moskalet al (2005) GLYX-13: A monoclonal antibody-derived peptide that acts as an N-methyl-D-aspartate receptor modulator. Neuropharmacology 49 1077. PMID: 16051282. |