| 货号 | 4827/10 |
| 别名 | (1R,5R,7R)-3-(3,4-Dihydroxybenzyol) |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity (IC50 values are 5 and 7 μM, respectively). Promotes expansion of human HSCs ex vivo. Causes reversal of EMT and inhibits β-catenin in breast cancer cell lines MDA-MB-231 and BT-549. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 602.8 |
| 分子式 | C38H50O6 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Ahmadet al (2012) Garcinol regulates EMT and Wnt signaling pathways in vitroandin vivo, leading to anticancer activity against breast cancer cells. Mol.Cancer.Ther. 11 2193. PMID: 22821148. Nishinoet al(2011)Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase. PLoS One 6 e24298. PMID: 21931675. Balasubramanyamet al (2004) Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. J.Biol.Chem. 279 33716. PMID: 15155757. |