| 货号 | 2085/10 |
| 别名 | 3-Cyclohexyl-N-[(9H-fluoren-9-ylmet |
| 供应商 | Tocris |
| 生物活性 | Novel non-peptide galanin GAL1 and GAL2 receptor agonist (Ki values are 11.7 and 34.1 μM respectively). Stimulates insulin release in isolated pancreatic islets from normal and diabetic rats. Systemically active in vivo; displays anticonvulsant activity following i.p. administration in mice. Central and peripheral administration also transiently inhibits food intake in rats and mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 678.83 |
| 分子式 | C40H46N4O6 |
| 可溶性/溶解性 | Soluble to 67.88 mg/ml in DMSO and to 16.97 mg/ml in ethanol with gentle warming |
| CAS号 | 475115-35-6 |
| 序列号 | AK (Modifications: Ala-1 = Fmoc-β-cyclohexyl-Ala, Lys-2 = Lys-(4-methyl-2-oxo-2H-1-benzo |
| 参考文献 | Luet al (2005) A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc.Natl.Acad.Sci. 102 874. PMID: 15647369. Quynhet al (2005) Effects of galnon, a non-peptide galanin-receptor agonist, on insulin release from rat pancreatic islets. Biochem.Biophys.Res.Comm. 328 213. PMID: 15670772. Abramovet al (2004) Regulation of feeding by galnon. Neuropeptides 38 55. PMID: 15003717. Saaret al (2002) Anticonvulsant activity of a nonpeptide galanin receptor agonist Proc.Natl.Acad.Sci.USA 99 7136. PMID: 12011470. |