| 货号 | 3377/1 |
| 供应商 | Tocris |
| 生物活性 | Selective vasopressin V1A receptor antagonist. Inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations in vitro(IC50 values are 5 and 30 nM respectively). Exhibits potent and prolonged antivasopressor activity and induces anxiolytic-like effects in the dorsal, but not ventral, hippocampus in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1151.38 |
| 分子式 | C52H74N14O12S2 |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| CAS号 | 73168-24-8 |
| 序列号 | YFQNCPRG (Modifications: Tyr-1 = Pmp-Tyr(Me), Gly-8 = C-terminal amide) |
| 参考文献 | Engin and Treit (2008) Dissociation of the anxiolytic-like effects of Avpr1a and Avpr1b receptor antagonists in the dorsal and ventral hippocampus. Neuropeptides 42 411. PMID: 18508119. Tsuchiyaet al (2002) Vasopressin inhibits sarcolemmal ATP-sensitive K+ channels via V1 receptors activation in the guinea pig heart. Circ.J. 66 277. PMID: 11922278. Spathet al (1996) Arginine vasopressin and oxytocin increase intracellular calcium and cAMP in human glomerular epithelial cells in culture. Kidney Blood Press.Res. 19 81. PMID: 8871886. Kruszynskiet al (1980) [1-(β-mercapto-β,β-cyclopentamethylenepropionic acid),2-(O-methyl)tyrosine]arginine-vasopressin and [1-(β-mercapto-β,β-cyclopentamethylenepropionic acid)]arginine-vasopressin, two highly potent antagonists of the vasopressor response to arginine-vasopressin. J.Med.Chem. 23 364. PMID: 6892930. |