GSK2879552
货号：
19403-5mg 基本售价：
1890.0 元 规格：
5 mg
产品信息
概述| 货号 | 19403-5mg |
| 描述 | GSK2879552 is a selective, orally bioavailable, mechanism-based inactivator of lysine-specific demethylase 1 (LSD1)/corepressor for element-1-silencing transcription factor (CoREST) activity.1 Inhibition of LSD1 via GSK2879552 has been shown to enhance H3K4 methylation and to increase the expression of tumor-suppressor genes.1,2 GSK2879552 demonstrates anti-proliferative growth effects (EC50s = 2-240 nM) in AML cell lines and is currently under clinical evaluation for cancer treatment.1,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mohammad, H.P.,Smitheman, K.N.,Kamat, C.D., et al. A DNA hypomethylation signature predicts antitumor activity of LSD1 inhibitors in SCLC. Cancer Cell 28(1), 57-69 (2015).
2.Maes, T.,Mascaró, C.,Ortega, A., et al. KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease. Epigenomics 7(4), 609-626 (2015).
3.Zheng, Y.C.,Yu, B.,Jiang, G.Z., et al. Irreversible LSD1 inhibitors: Application of tranylcypromine and its derivatives in cancer treatment. Current Topics in Medicinal Chemistry Feb, (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 364.5 |
| 分子式 | C23H28N2O2 |
| CAS号 | 1401966-69-5 |
| 稳定性 | ≥ 2 years |
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