| 货号 | 20315-5mg |
| 描述 | MMP-2/MMP-9 inhibitor I is a potent inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 (IC50s = 310 and 240 nM, respectively).1 It acts by binding zinc at the active site of these MMPs. MMP-2/MMP-9 inhibitor I is active in vivo as well as in vitro and blocks MMP-2/MMP-9-dependent invasion, tumor growth, and metastasis in both cell culture and mouse tumor models.1 This compound has been used to elucidate the roles of MMP-2 and MMP-9 in diverse systems, including mammary epithelial cell transformation, neuronal dysfunction, lymphocyte recruitment, and progressive hereditary kidney disease.2,3,4,5 |
| 别名 | Metalloproteinase-2/Metalloproteinase-9 Inhibitor I; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tamura, Y.,Watamane, F.,Nakatani, T., et al. Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives. J. Med. Chem. 41(4), 640-649 (1998). 2.Dechow, T.B.,Pedranzini, L.,Leitch, A., et al. Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C. Proc. Natl. Acad. Sci. USA 101(29), 10602-10607 (2004). 3.Lim, K.,Hyun, Y.-M.,Lambert-Emo, K., et al. Neutrophil trails guide influenza-specific CD8⁺ T cells in the airways. Science 349(6252), (2015). 4.Mizoguchi, H.,Yamada, K., and Nabeshima, T. Matrix metalloproteinases contribute to neuronal dysfunction in animal models of drug dependence, Alzheimer’s disease, and epilepsy. 2011:681385, (2011). 5.Zeisberg, M.,Khurana, M.,Rao, V.H., et al. Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. PLoS Med. 3(4), (2006). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥99% |
| 计算分子量 | 381.4 |
| 分子式 | C21H19NO4S |
| CAS号 | 193807-58-8 |
| 稳定性 | ≥ 1 year |
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