| 货号 | 2757/1 |
| 别名 | 1,4-trans-1-(1-Cycloocten-1-ylmethy |
| 供应商 | Tocris |
| 生物活性 | Potent chemokine CCR1 and CCR3 receptor antagonist. Inhibits MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants (IC50 values are 9.57 and 93.8 nM respectively). Antagonizes CCR3-mediated entry of HIV-1 isolate 89.6 into NP-2 cells (IC50 = 57 nM). Isomer of J 113863 (Cat. No. 2595). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 655.44 |
| 分子式 | C30H37Cl2IN2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| CAS号 | 301648-08-8 |
| 参考文献 | Lopes de Mendoncaet al (2005) Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist. J.Biol.Chem. 280 4808. PMID: 15548526. Sabroeet al (2000) A small molecule antagonist of chemokine receptors CCR1 and CCR3. J.Biol.Chem. 275 25985. PMID: 10854442. |