| 货号 | 5215/1 |
| 别名 | N-[2-[[[3-(4-Chlorophenyl)-2-propen |
| 供应商 | Tocris |
| 生物活性 | CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 599.03 |
| 分子式 | C26H29ClN2O4 |
| 可溶性/溶解性 | Soluble to 10 mM in water |
| 参考文献 | Brunoet al (2010) Microwave-assisted synthesis of KN-93, a potent and selective inhibitor or Ca2+/Calmoduline-dependent protein kinase II. Synthesis 244193. Rezazadehet al (2006) KN-93 (2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]-amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels. J.Pharmacol.Exp.Ther. 317 292. PMID: 16368898. Andersonet al (1998) KN-93, an inhibitor of multifunctional Ca2+/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J.Pharmacol.Exp.Ther. 287 996. PMID: 9864285. Sumiet al (1991) The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine content in PC12h cells. Biochem.Biophys.Res.Comm. 181 968. PMID: 1662507. |