| 货号 | 15124-100ug |
| 描述 | Ilimaquinone is a natural sesquiterpene quinone that has antimicrobial, anti-HIV, anti-mitotic, and anti-inflammatory properties.1 In mammalian cells, 25 µM ilimaquinone reversibly induces vesiculation of Golgi membranes, blocking the secretory pathway.2,3 It inhibits the conversion of S-adenosylhomocysteine (SAH) to homocysteine by SAH hydrolase (IC50 = 40 µM).1,4 Ilimaquinone also inhibits DNA polymerase β and dual specificity phosphatase Cdc25B (IC50 = 45.2 and 92 µM, respectively) and, at 10 µM, activates gene expression through hypoxia-inducible factor-1.5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Radeke, H.S.,Digits, C.A.,Casaubon, R.L., et al. Interactions of (−)-ilimaquinone with methylation enzymes: Implications for vesicular-mediated secretion. Chemistry & Biology 6(9), 639-647 (1999). 2.Takizawa, P.A.,Yucel, J.K.,Veit, B., et al. Complete vesiculation of golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, ilimaquinone. Cell 73(6), 1079-1090 (1993). 3.Cruciani, V.,Leithe, E. and Mikalsen, S.O. Ilimaquinone inhibits gap-junctional communication prior to Golgi fragmentation and block in protein transport. Experimental Cell Research 287(1), 130-142 (2003). 4.Kim, B.G.,Chun, T.G.,Lee, H.Y., et al. A new structural class of S-adenosylhomocysteine hydrolase inhibitors. Bioorganic & Medicinal Chemistry 17(18), 6707-6714 (2009). 5.Cao, S.,Gao, Z.,Thomas, S.J., et al. Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase β. Journal of Natural Products 67(10), 1716-1718 (2004). 6.Du, L.,Zhou, Y.D. and Nagle, D.G. Inducers of hypoxic response: Marine sesquiterpene quinones activate HIF-1. Journal of Natural Products 76(6), 1175-1181 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 358.5 |
| 分子式 | C22H30O4 |
| CAS号 | 71678-03-0 |
| 稳定性 | ≥ 2 years |
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