| 货号 | 13165-5mg |
| 描述 | (+)-Blebbistatin is the inactive enantiomer of (-)-blebbistatin (Item No. 13013), which is a selective inhibitor of non-muscle myosin II ATPases.1,2 Prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications.3,4 (R)-nitro-Blebbistatin (Item No. 9001935) is a more stable form of (+)-blebbistatin.5 The addition of a nitro group stabilizes the molecule to circumvent its degradation by prolonged blue light exposure. (R)-nitro-Blebbistatin has the same stereochemistry as the inactive (+)-blebbistatin enantiomer. |
| 别名 | (R)-Blebbistatin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Straight, A.F.,Cheung, A.,Limouze, J., et al. Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor. Science 299(5613), 1743-1747 (2003). 2.Kovács, M.,Tóth, J.,Hetényi, C., et al. Mechanism of blebbistatin inhibition of myosin II. J. Biol. Chem. 279(34), 35557-35563 (2004). 3.Kolega, J. Phototoxicity and photoinactivation of blebbistatin in UV and visible light. Biochem. Biophys. Res. Commun. 320(3), 1020-1025 (2004). 4.Sakamoto, T.,Limouze, J.,Combs, C.A., et al. Blebbistatin, a myosin II inhibitor, is photoinactivated by blue light. Biochemistry 44(2), 584-588 (2005). 5.Lucas-Lopez, C.,Patterson, S.,Blum, T., et al. Absolute stereochemical assignment and fluorescence tuning of the small molecule tool, (−)-blebbistatin. European J. Org. Chem. 2005(9), 1736-1740 (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 292.3 |
| 分子式 | C18H16N2O2 |
| CAS号 | 1177356-70-5 |
| 稳定性 | ≥ 2 years |
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