| 货号 | 4302/50 |
| 别名 | (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(Et |
| 供应商 | Tocris |
| 生物活性 | Angiotensin-converting enzyme (ACE) inhibitor (IC50 = 1.05 nM). Brain penetrant. Suppresses the increase in hippocampal ACE activity and improves cognition in PS2APP-transgenic mice. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 441.6 |
| 分子式 | C19H32N2O5 |
| 可溶性/溶解性 | Soluble to 50 mM in ethanol |
| 参考文献 | Donget al (2011) Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease. FASEB J. 25 2911. PMID: 21593435. Ceconiet al (2007) Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur.J.Pharmacol. 577 1. PMID: 17716647. Takaiet al (2004) Significant target organs for hypertension and cardiac hypertrophy by angiotensin-converting enzyme inhibitors. Hypertens.Res. 27 213. PMID: 15080380. |