货号 | 1505/100 |
别名 | 6-(1,3-Dihydro-4-hydroxy-6-methoxy- |
供应商 | Tocris |
生物活性 | Immunosuppressive agent with antiviral and antitumor effects in vitroandin vivo. Potently inhibits inosine monophosphate dehydrogenase, thus inhibiting de novo GTP synthesis leading to decreased RNA and DNA synthesis. Reversibly inhibits proliferation of T and B lymphocytes and antibody formation. |
运输条件 | Blue Ice |
存放说明 | Ambient |
纯度 | >98 % |
计算分子量 | 320.34 |
分子式 | C17H20O6 |
可溶性/溶解性 | Soluble to 100 mM in DMSO |
CAS号 | 24280-93-1 |
参考文献 | Goldberget al (1998) Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J.Pharmacol.Exp.Ther. 286 1007. PMID: 9694962. Chapmanet al (1997) Distinct inhibitory effects of spinal endomorphin-1 and endomorphin-2 on evoked dorsal horn neuronal responses in the rat. Br.J.Pharmacol. 122 1537. PMID: 9422796. Zadinaet al (1997) A potent and selective endogenous agonist for the μ-opiate receptor. Nature 386 499. PMID: 9087409. Sendaet al (1995) Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells. Transplantation 60 1143. PMID: 7482723. Allisonet al (1993) Mechanisms of action of mycophenolic acid. Ann.N.Y.Acad.Sci. 696 63. PMID: 7906496. Euguiet al (1991) Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depeletion. Scand.J.Immunol. 33 161. PMID: 1826793. |