| 货号 | 2575/1 |
| 别名 | N-[(2R)-4-Hydroxyamino)-1,4-dioxo-2 |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of the major neurotensin and neuromedin N degrading enzymes (IC50 values are 31, 40, 52 and 58 nM for endopeptidase 24.15, endopeptidase 24.11, leucine aminopeptidase and endopeptidase 24.16 respectively). Exhibits analgesic effects in various nociception assays. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 449.54 |
| 分子式 | C23H35N3O6 |
| 可溶性/溶解性 | Soluble to 0.80 mg/ml in sodium bicarbonate (0.01M) |
| 序列号 | XIL (Modifications: X-1 = N-[(2R)-4-Hydroxyamino)-1,4-di |
| 参考文献 | Menardet al (1996) The cytotoxic activity of Bacillus anthracis lethal factor is inhibited by leukotriene A4 hydrolase and metallopeptidase inhibitors. Biochem.J. 320 687. PMID: 8973585. Doulutet al (1993) Synthesis and analgesic effects of N-[3-[(hydroxyamino) carbonyl]-1-oxo-2(R)-benzylpropyl]-L-isoleucyl-L-leucine, a new potent inhibitor of multiple neurotensin/neuromedin N degrading enzymes. J.Med.Chem. 36 1369. PMID: 8496905. Kitabgiet al (1992) Effects of thiorphan, bestatin and a novel metallopeptidase inhibitor JMV 390-1 on the recovery of neurotensin and neuromedin N released from mouse hypothalamus. Neurosci.Lett. 142 200. PMID: 1454216. |