| 货号 | 3309/50 |
| 别名 | (±)-(3R*,5S*,6E)-7-[3-(4-Fluoropheny |
| 供应商 | Tocris |
| 生物活性 | Orally active, potent and competitive HMG-CoA reductase inhibitor (IC50 = 40 -100 nM at human liver microsomes). Inhibits vascular smooth muscle proliferation in vitro(IC50 = 70 nM) and exhibits antihypercholesterolemic and antioxidant activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 433.45 |
| 分子式 | C24H25FNNaO4 |
| 可溶性/溶解性 | Soluble to 25 mM in water and to 100 mM in DMSO |
| CAS号 | 93957-55-2 |
| 参考文献 | Turneret al (2007) Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J.Cardiovasc.Pharmacol. 50 458. PMID: 18049315. Yamamotoet al (2001) Antioxidative effects of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes. J.Pharm.Pharmacol. 53 227. PMID: 11273020. Dansetteet al (2000) HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins. Exp.Toxicol.Pathol. 52 145. PMID: 10965989. |