| 货号 | 3022/10 |
| 别名 | (7R)-4-Hydroxy-7-methoxy-N,N,N-trim |
| 供应商 | Tocris |
| 生物活性 | Synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C (IC50= 9.6 μM in fibroblasts and adenocarcinoma cells). Also acts as an agonist at platelet-activating factor (PAF) receptors. Antitumor lipid; selectively induces apoptosis in tumor cells, sparing normal cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 523.73 |
| 分子式 | C27H58NO6P |
| 可溶性/溶解性 | Soluble to 5 mM in water with gentle warming and to 100 mM in ethanol |
| CAS号 | 77286-66-9 |
| 参考文献 | Shimizuet al (2007) Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats. Eur.J.Pharmacol. 571 138. PMID: 17628524. Wonget al (2007) Phospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesis. BMC Cell Biol. 8 15. PMID: 17509155. Aokiet al (1995) A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor. J.Immunol.Methods 186 225. PMID: 7594622. Powiset al (1992) Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues. Cancer Res. 52 2835. PMID: 1316230. |