| 货号 | 0786/50 |
| 别名 | 3-Methyl-1-phenyl-2-pyrazolin-5-one |
| 供应商 | Tocris |
| 生物活性 | A radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 174.2 |
| 分子式 | C10H10N2O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 89-25-8 |
| 参考文献 | Kawasakiet al (2007) Edaravone (3methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum. J.Pharmacol.Exp.Ther. 322 274. PMID: 17429058. Kawaiet al (1997) Effects of a novel free radical scavenger, MC-186, on ischemic brain damage in rat distal middle cerebral artery occlusion model. J.Pharmacol.Exp.Ther. 281 921. PMID: 9152402. Watanabeet al (1994) Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J.Pharmacol.Exp.Ther. 268 1597. PMID: 8138971. |