| 货号 | 3541/1 |
| 别名 | (R)-α-Cyclopentyl-4-(2-quinolinylmet |
| 供应商 | Tocris |
| 生物活性 | 5-lipoxygenase activating protein (FLAP) inhibitor. Inhibits the synthesis of leukotrienes B4 and C4 in animal models; inhibits synthesis of leukotriene B4 in A23187-stimulated leukocytes (IC50 values are 0.026, 0.039 and 0.22 μM for rat, mice and human leukocytes respectively). Displays anti-inflammatory activity. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 361.43 |
| 分子式 | C23H23NO3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Hatzelmannet al (1994) Mode of action of the leukotriene synthesis (FLAP) inhibitor BAY X 1005: implications for biological regulation of 5-lipoxygenase. Agents Actions 43 64. PMID: 7741044. Fruchtmannet al (1993) In vitro pharmacology of BAY X1005, a new inhibitor of leukotriene synthesis. Agents Actions 38 188. PMID: 8213345. Muller-Peddinghauset al (1993) BAY X1005, a new inhibitor of leukotriene synthesis: in vivo inflammation pharmacology and pharmacokinetics. J.Pharmacol.Exp.Ther. 267 51. PMID: 8229782. |