| 货号 | 2132/50 |
| 别名 | 4-Amino-N-[(1-ethyl-2-pyrrolidinyl) |
| 供应商 | Tocris |
| 生物活性 | Potent, selective dopamine D2 and D3 receptor antagonist. Ki values are 2.8 and 3.2 nM respectively for human D2 and D3 and > 1000 nM for human D1, D4 and D5 receptors. Shows selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic D2/D3 receptors at higher doses. Preferentially interacts with limbic D2-like receptors in vivo. Atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 369.48 |
| 分子式 | C17H27N3O4S |
| 可溶性/溶解性 | Soluble to 25 mM in 1eq. HCl with gentle warming and to 50 mM in DMSO |
| CAS号 | 71675-85-9 |
| 参考文献 | Moller (2003) Amisulpride: limbic specificity and the mechanism of antipsychotic atypicality. Prog.Neuro-Psychopharm.Biol.Psychiat. 271101. Perraultet al (1997) Psychopharmacological profile of amisulpride: an antipsychotic drug with presynaptic D2/D3 dopamine receptor antagonist activity and limbic selectivity. J.Pharmacol.Exp.Ther. 280 73. PMID: 8996184. Schoemakeret al (1997) Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity. J.Pharmacol.Exp.Ther. 280 83. PMID: 8996185. |