1,2,3,4,5,6-Hexabromocyclohexane (50 MG)
货号：
2291/50 基本售价：
1715.2 元 规格：
50 mg
产品信息
概述| 货号 | 2291/50 |
| 别名 | 1,2,3,4,5,6-Hexabromocyclohexane; NSC 7908 |
性能| 供应商 | Tocris |
| 生物活性 | Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μM of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μM elimates nearly all JAK2 activity. Non-cytotoxic at 100 μM. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 557.54 |
| 分子式 | C6H6Br6 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO with gentle warming |
| CAS号 | 1837-91-8 |
| 参考文献 | Sandberget al (2005) Identification of 1,2,3,4,5,6-Hexabromocyclohexane as a small molecule inhibitor of Jak2 tyrosine kinase autophosphorylation. J.Med.Chem. 48 2526. PMID: 15801842. |
