Gefitinib
货号：
4765S 基本售价：
1690.0 元 规格：
10mg
产品信息
性能| 供应商 | CST |
| 背景 | Gefitinib is a novel and potent EGFR tyrosine kinase inhibitor that binds to the ATP-binding site of the enzyme, and has been shown to be competitive with ATP and noncompetitive with peptide substrates (1). Gefitinib inhibits in vitro EGFR activity (IC50 = 33 nM), significantly inhibits EGF-stimulated tumor cell growth (IC50 = 54 nM) when compared to the absence of EGF (IC50 = 8.8 µM), and effectively blocks EGF-stimulated autophosphorylation in tumor cells. It also selectively inhibits EGF-stimulated growth of HUVE cells compared with FGF- or VEGF-stimulated growth (1). Although studies demonstrate gefitinib to be much more selective for EGFR than HER2 (1,2), it has also shown to inhibit growth and phosphorylation of HER2 in numerous HER2-overexpressing cell lines (3). |
| 存放说明 | -20C |
参考图片Chemical structure of gefitinib.吉非替尼的化学结构。 |
