| 货号 | 14902-1mg |
| 描述 | Luffariellolide is a natural sesterterpenoid which reversibly inhibits secretory phospholipase A2 isoforms from bee venom (IC50 = 230 nM) and snake venom, reducing inflammation.1 It blocks the production of platelet-activating factor in stimulated neutrophils (IC50 = 5 μM).2 Luffariellolide is also a structural mimic of all-trans retinoic acid (RA) and, at 1 μM, acts as an agonist for the RA receptors RAR α, β, and γ but not for other nuclear receptors.3 In RA-sensitive cancer cell lines, luffariellolide induces the expression of RAR target genes and inhibits cell growth.3 It also inhibits the activation of hypoxia-inducible factor by hypoxia (IC50 = 3.6 μM).4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Calhoun, W.,Yu, J.,Sung, A., et al. Pharmacologic modulation of D-49 phospholipase A2-induced paw edema in the mouse. Agents and Actions 27, 418-421 (1989). 2.Glaser, K.B.,Lock, Y.W. and Chang, J.Y. PAF and LTB4 biosynthesis in the human neutrophil: Effects of putative inhibitors of phospholipase A2 and specific inhibitors of 5-lipoxygenase. Agents and Actions 34, 89-92 (1991). 3.Wang, S.,Wang, Z.,Lin, S., et al. Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells. Biochemistry Journal 446(1), 79-87 (2012). 4.Li, J.,Du, L.,Kelly, M., et al. Structures and potential antitumor activity of sesterterpenes from the marine sponge Hyrtios communis. Journal of Natural Products 76(8), (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 386.6 |
| 分子式 | C25H38O3 |
| CAS号 | 111149-87-2 |
| 稳定性 | ≥ 6 months |
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