| 货号 | 2625/10 |
| 别名 | 1,2-Benzisoxazole-3-methanesulfonam |
| 供应商 | Tocris |
| 生物活性 | Antiepileptic that possesses a broad spectrum anticonvulsant and mechanistic profile. Blocks voltage-sensitive Na+ and T-type Ca2+ channels, stimulates BKCa channels, modulates GABA, glutamate and monoamine neurotransmission, inhibits lipid peroxidation and scavenges hydroxyl and nitric oxide free radicals. Displays neuroprotective and antiParkinsonian activity. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 212.22 |
| 分子式 | C8H8N2O3S |
| 可溶性/溶解性 | Soluble to 10 mM in water and to 100 mM in DMSO |
| CAS号 | 68291-97-4 |
| 参考文献 | Huanget al (2007) Activation by Zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells. J.Pharmacol.Exp.Ther. 321 98. PMID: 17255467. Glucket al (2004) Novel dopamine releasing response of an anti-convulsant agent with possible anti-Parkinson's activity. J.Neural Transm. 111 713. PMID: 15168218. Sobieszeket al (2003) Zonisamide: a new antiepileptic drug. Pol.J.Pharmacol. 55 683. PMID: 14704463. Tokumaruet al (2000) In vivo evaluation of hippocampal anti-oxidant ability of zonisamide in rats. Neurochem.Res. 25 1107. PMID: 11055748. |