| 货号 | 5907/50 |
| 别名 | N-[4-[[4-(4-Methyl-1-piperazinyl)-6 |
| 供应商 | Tocris |
| 生物活性 | High affinity and selective Aurora kinase inhibitor (Ki values are 0.6, 5 and 18 nM for Aurora A, Aurora C and Aurora B, respectively). Also exhibits affinity for FLT-3 and Abl. Exhibits selectivity for Aurora kinase over 190 other protein kinases. Inhibits proliferation and induces apoptosis in a number of cancer cell lines in vitro. Reduces tumor size in leukemia and colon cancer cell xenografts in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 464.59 |
| 分子式 | C23H28N8OS |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Bebbingtonet al (2009) The discovery of the potent aurora inhibitor MK-0457 (VX-680). Bioorg.Med.Chem.Lett. 19 3586. PMID: 19447622. Harringtonet al (2004) VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat.Med. 10 262. PMID: 14981513. |