| 货号 | 2200S |
| 供应商 | CST |
| 背景 | An anti-tumor agent that is commonly used as an apoptosis inducer, etoposide (VP-16) is a topoisomerase II inhibitor with an IC50 of 59.2 µM (1). Etoposide stabilizes a covalent topoisomerase II-cleaved DNA intermediate complex in the catalytic cycle of the enzyme, leading to genomic instability and cell death (2,3). This mechanism of action has been shown to delay progression of the cell cycle through the late S and early G2 phase (4,5). |
| 存放说明 | -20C |
| 参考文献 | 1 . Terada, T. et al. (1993) J Med Chem 36, 1689-99. 2 . Baldwin, E.L. and Osheroff, N. (2005) Curr Med Chem Anticancer Agents 5, 363-72. 3 . Li, T.K. and Liu, L.F. (2001) Annu. Rev. Pharmacol. Toxicol. 41, 53-77. 4 . Dołega, A. (1998) Postepy Hig Med Dosw 52, 67-87. 5 . Smith, P.J. et al. (1994) Br J Cancer 70, 914-21. |
Chemical structure of etoposide.依托泊苷的化学结构。 |
