UNC0379
货号：
16400-5mg 基本售价：
1050.0 元 规格：
5 mg
产品信息
概述| 货号 | 16400-5mg |
| 描述 | SET domain-containing protein 8 (SET8) is a methyltransferase that selectively mono-methylates histone H4 at lysine residue 20, an event proven to have an important role in chromatin structure and transcriptional activation. It is also a regulator of p53, mono-methylating lysine 382 of the tumor suppressor. UNC0379 is a substrate-competitive inhibitor of the lysine methyltransferase SET8 (IC50 = 7.3 µM; Kd = 18.3 µM).1 It is selective for SET8 over 15 other methyltransferases, including G9a and GLP (IC50s = >100 µM).1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ma, A.,Yu, W.,Li, F., et al. Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. Journal of Medicinal Chemistry (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 413.6 |
| 分子式 | C23H25N5O2 |
| CAS号 | 1620401-82-2 |
| 稳定性 | ≥ 2 years |
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