TPCA-1
货号：
15115-500ug 基本售价：
770.0 元 规格：
500 ug
产品信息
概述| 货号 | 15115-500ug |
| 描述 | TPCA-1 is a selective inhibitor of IκB kinase-2 (IC50s = 17.9 nM and 0.40 μM for IKK2 and IKK1, respectively).1 Furthermore, it displays greater than 550-fold selectivity over other kinases and enzymes including, p38, MAPK, COX, and JNK.1 TPCA-1 inhibits the production of LPS-induced TNF-α, IL-6, and IL-8 with IC50 values equal to 0.17, 0.29, and 0.32 μM, respectively.1 At 20 mg/kg, TPCA-1 has been used to reduce the severity and onset of collagen-induced arthritis in mice and at 30 mg/kg to block cytokine release in an antigen-driven rat model of lung inflammation.1,2 |
| 别名 | IKK2 Inhibitor IV; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Podolin, P.L.,Callahan, J.F.,Bolognese, B.J., et al. Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IκB kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell proliferation. Journal of Pharmacology and Experimental Therapeutics 312(1), 373-381 (2005).
2.Birrell, M.A.,Hardaker, E.,Wong, S., et al. IκB kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma. American Journal of Respiration and Critical Care Medicine 172(8), 962-971 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 279.3 |
| 分子式 | C12H10FN3O2S |
| CAS号 | 507475-17-4 |
| 稳定性 | ≥ 2 years |
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