SC-79
货号：
14972-5mg 基本售价：
770.0 元 规格：
5 mg
产品信息
概述| 货号 | 14972-5mg |
| 描述 | SC-79 is an activator of Akt that blocks its membrane translocation while allowing its phosphorylation, in the cytosol, by upstream kinases.1 For example, both Thr308 and Ser473 on Akt are phosphorylated in serum starved HeLa cells treated for 1 hour with insulin growth factor and SC-79 (4 µg/ml).1 SC-79 permits phosphorylation and activation of all isoforms of Akt, it is active in multiple cell types, and works in both receptor tyrosine kinase- and G protein-coupled receptor-mediated signaling.1 SC-79 has been used to elucidate the role of Akt signaling in neuronal survival, glucose-mediated apoptosis in podocytes, and miR-221-regulated cancer cell proliferation.2,1,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jo, H.,Mondal, S.,Tan, D., et al. Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc.Nat.Acad.Sci.USA 109(26), 10581-10586 (2012).
2.Li, C. and Siragy, H.M. (Pro)renin receptor regulates autophagy and apoptosis in podocytes exposed to high glucose. Am.J.Physiol.Endocrinol.Metab. 309(3), E302-E310 (2015).
3.Yang, W.,Yang, Y.,Xia, L., et al. MiR-221 promotes capan-2 pancreatic ductal adenocarcinoma cells proliferation by targeting PTEN-Akt. Cell.Physiol.Biochem. 38(6), 2366-2374 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 364.8 |
| 分子式 | C17H17ClN2O5 |
| CAS号 | 305834-79-1 |
| 稳定性 | ≥ 2 years |
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