| 货号 | 10523-5mg |
| 描述 | Sirtinol is a cell-permeable inhibitor of sirtuin NAD+-dependent deacetylases, inhibiting the yeast sirtuin Sir2p with an IC50 value of 68 μM and the human sirtuins SIRT1 and SIRT2 with IC50 values of 131 and 38 μM, respectively.1 It does not alter HDAC1 activity.1 Sirtinol inhibits the growth of cancer cells and suppresses inflammatory signaling in human dermal microvascular endothelial cells.2,3,4 In plants, sirtinol can be metabolized to 2-hydroxy-1-naphthoic acid, which activates auxin signaling and alters plant growth and development.5,6 |
| 别名 | Sir Two Inhibitor Naphthol; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Grozinger, C.M.,Chao, E.D.,Blackwell, H.E., et al. Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. The Journal of Biological Chemisty 276(42), 38837-38843 (2001). 2.Ota, H.,Tokunaga, E.,Chang, K., et al. Sirt1 inhibitor, sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene 25, 176-185 (2006). 3.Cea, M.,Soncini, D.,Fruscione, F., et al. Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells. PLoS One 6(7), 1-12 (2011). 4.Orecchia, A.,Scarponi, C.,Di Felice, F., et al. Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cells. PLoS One 6(9), 1-12 (2011). 5.Zhao, Y.,Dai, X.,Blackwell, H.E., et al. SIR1, an upstream component in auxin signaling identified by chemical genetics. Science 301, 1107-1110 (2003). 6.Dai, X.,Hayashi, K.i.,Nozaki, H., et al. Genetic and chemical analyses of the action mechanisms of sirtinol in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America 102(8), 3129-3134 (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 394.5 |
| 分子式 | C26H22N2O2 |
| CAS号 | 410536-97-9 |
| 稳定性 | ≥ 2 years |
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