| 货号 | 14913-10mg |
| 描述 | Arctigenin is an extract from A. lappa, a burdock plant traditionally used in Japanese Kampo medicine for its antioxidant, anti-inflammatory, antiproliferative, and antiviral activity. At 0.1 μM, arctigenin can block the activation of Akt induced by glucose starvation in pancreatic cancer PANC-1 cells, which is a key process in the tolerance exhibited by cancer cells to glucose starvation.1 It has potent in vitro antiviral activities against influenza A virus and shows neuroprotective effects against an experimental mouse model of Japanese encephalitis.2,3 Arctigenin also demonstrates a therapeutic effect in ischemic stroke treatment of middle cerebral artery occluded rats by suppressing microglia activation and decreasing IL-1β and TNF-α expression.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Awale, S.,Lu, J.,Kalauni, S.K., et al. Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation. Cancer Research 66(3), 1751-1757 (2006). 2.Hayashi, K.,Narutaki, K.,Nagaoka, Y., et al. Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus. Biological and Pharmaceutical Bullentin 33(7), 1199-1205 (2010). 3.Swarup, V.,Ghosh, J.,Mishra, M.K., et al. Novel strategy for treatment of Japanese encephalitis using arctigenin, a plant lignan. Journal of Antimicrobial Chemotherapy 61(3), 679-688 (2008). 4.Fan, T.,Jiang, W.L.,Zhu, J., et al. Arctigenin protects focal cerebral ischemia-reperfusion rats through inhibiting neuroinflammation. Biological and Pharmaceutical Bullentin 35(11), 2004-2009 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 372.4 |
| 分子式 | C21H24O6 |
| CAS号 | 7770-78-7 |
| 稳定性 | ≥ 2 years |
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