Leupeptin (hemisulfate)
货号：
14026-10mg 基本售价：
686.0 元 规格：
10 mg
产品信息
概述| 货号 | 14026-10mg |
| 描述 | Leupeptin is a reversible inhibitor of cysteine, serine, and threonine proteases that is produced naturally by Streptomyces.1 It has been reported to inhibit cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.1 Leupeptin has been shown to be protective of auditory hair cells exposed to disruptive noise or ototoxic aminoglycoside-type antibiotics.2,3 It is also widely used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest. |
| 别名 | Acetyl-L-leucyl-L-leucyl-L-argininal; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mehdi, S. Cell-penetrating inhibitors of calpain. Trends in Biochemical Sciences 16(4), 150-153 (1991).
2.Gavriel, H.,Shulman, A.,Stracher, A., et al. Leupeptin reduces impulse noise induced hearing loss. J.Occup.Med.Toxicol. 6, 38 (2011).
3.Momiyama, J.,Hashimoto, T.,Matsubara, A., et al. Leupeptin, a calpain inhibitor, protects inner ear hair cells from aminoglycoside ototoxicity. Tohoku Journal of Experimental Medicine 209(2), 89-97 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 475.6 |
| 分子式 | C20H38N6O4 • 1/2H2SO4 |
| CAS号 | 103476-89-7 |
| 稳定性 | ≥ 2 years |
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