| 货号 | 21809-10g |
| 描述 | L-Alanyl-L-glutamine is a synthetic glutamine dipeptide that can attenuate oxidative stress in rodent models when administered at doses of 0.75-1.5 mg/kg.1,2,3,4In vivo, the parenteral administration of L-alanyl-L-glutamine to Swiss mice yields higher plasma glutamine levels compared to enteral administration.5In vitro, the addition of this dipeptide (50 mM) to cultures of antibody-producing CHO cells reduces apoptosis and promotes antibody production.6 Treatment of insulin-secreting BRIN-BD11 β-cells with L-alanyl-L-glutamine (2 mM) protects against the inflammatory effects of exposure to lipopolysaccharide-treated primary macrophages.7 |
| 别名 | Ala-Gln;L-Ala-L-Gln; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Pires, V.L.d.S.,de Souza, J.R.F.,Guimarães, S.B., et al. Preconditioning with L-alanyl-L-glutamine in a Mongolian gerbil model of acute cerebral ischemia/reperfusion injury. Acta Cir. Bras. 26(Suppl 1), 14-20 (2011). 2.Petry, É.R.,Cruzat, V.F.,Heck, T.G., et al. Alanyl-glutamine and glutamine plus alanine supplements improve skeletal redox status in trained rats: Involvement of heat shock protein pathways. Life Sci. 94(2), 130-136 (2014). 3.Cruzat, V.F.,Bittencourt, A.,Scomazzon, S.P., et al. Oral free and dipeptide forms of glutamine supplementation attenuate oxidative stress and inflammation induced by endotoxemia. Nutrition 30(5), 602-611 (2014). 4.Chuang, I.-C.,Huang, M.-S.,Huang, L.-J., et al. Prophylactic inhalation of L-alanyl-L-glutamine enhances heat shock protein 72 and attenuates endotoxin-induced lung injury in rats. Physiol. Res. 64(4), 505-512 (2015). 5.Boelens, P.G.,Melis, G.C.,van Leeuwen, P.A., et al. Route of administration (enteral or parenteral) affects the contribution of L-glutamine to de novo L-arginine synthesis in mice: a stable-isotope study. Am. J. Physiol. Endocrinol. Metab. 291(4), E683-E690 (2006). 6.Imamoto, Y.,Tanaka, H.,Takahashi, K., et al. Advantages of AlaGln as an additive to cell culture medium: Use with anti-CD20 chimeric antibody-producing POTELLIGENT™ CHO cell lines. Cytotechnology 65(1), 135-143 (2013). 7.Cruzat, V.F.,Keane, K.N.,Scheinpflug, A.L., et al. Alanyl-glutamine improves pancreatic β-cell function following ex vivo inflammatory challenge. J. Endocrinol. 224(3), 261-271 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥95% |
| 计算分子量 | 217.2 |
| 分子式 | C8H15N3O4 |
| CAS号 | 39537-23-0 |
| 稳定性 | ≥ 2 years |
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