| 货号 | 15212-100mg |
| 描述 | Ketoconazole is an orally active broad spectrum antifungal agent that blocks ergosterol biosynthesis by inhibiting the fungal cytochrome P450 (CYP) isoform CYP51, also known as lanosterol 14α-demethylase.1,2 It potently inhibits the mammalian analog CYP51A1 (IC50 = 63.5 nM), as well as a variety of other CYP isoforms.3,4,5,6,2 |
| 别名 | Nizoral;R 41400; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Vanden Bossche, H.,Marichal, P.,Gorrens, J., et al. Biochemical approaches to selective antifungal activity. Focus on azole antifungals. Mycoses 32(Suppl 1), 35-52 (1989). 2.Dilmaghanian, S.,Gerber, J.G.,Filler, D.G., et al. Enantioselectivity of inhibition of cytochrome P450 3A4 (CYP3A4) by ketoconazole: Testosterone and methadone as substrates. Chirality 16(2), 79-85 (2004). 3.Walker, K.A.M.,Kertesz, D.J.,Rotstein, D.M., et al. Selective inhibition of mammalian lanosterol 14α-demethylase: A possible strategy for cholesterol lowering. Journal of Medicinal Chemistry 36(15), 2235-2237 (1993). 4.Njar, V.C.O.,Kato, K.,Nnane, I.P., et al. Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17α-hydroxylase-C17,20-lyase (P45017α): Potential agents for the treatment of prostate cancer. Journal of Medicinal Chemistry 41(6), 902-912 (1998). 5.McNulty, J.,Nair, J.J.,Wurgun, N., et al. Discovery of a novel class of aldol-derived 1,2,3-triazoles: Potent and selective inhibitors of human cytochrome P450 19A1 (aromatase). Bioorganic & Medicinal Chemistry Letters 22(1), 718-722 (2012). 6.Rotstein, D.M.,Kertesz, D.J.,Walker, K.A., et al. Stereoisomers of ketoconazole: Preparation and biological activity. Journal of Medicinal Chemistry 35(15), 2818-2825 (1992). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 531.4 |
| 分子式 | C26H28Cl2N4O4 |
| CAS号 | 65277-42-1 |
| 稳定性 | ≥ 2 years |
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