| 货号 | 14610-100mg |
| 描述 | Thalidomide was prescribed as an anti-nausea agent to help pregnant women with morning sickness in the late 1950s. It was found to be a potent teratogen, causing many different forms of birth defects and was withdrawn from the market.1 Thalidomide and synthetic analogs have recently been proven effective in treating inflammation associated with diseases such as leprosy, arthritis and Crohn’s disease, and in cancers such as multiple myeloma.1,2 The direct target for the teratogenicity of thalidomide was not discovered until 2010, when it was found that it interacts directly with the protein cereblon (CRBN; IC50 = 8.5 nM), a ubiquitously-expressed E3 ligase.3 Binding of thalidomide analogs to CRBN-DNA damage binding protein-1 complexes account for the immunomodulatory and antiproliferative effects of these compounds.4 |
| 别名 | Contergan;Kevadon;NSC 66847;NSC 527179; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sakata, T. and Chen, J.K. Chemical Jekyll and Hyde’s: Small-molecule inhibitors of developmental signaling pathways. Chem.Soc.Rev. 40(8), 4318-4331 (2011). 2.Zhu, Y.X.,Kortuem, K.M. and Stewart, A.K. Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leukemia and Lymphoma 54(4), 683-687 (2013). 3.Ito, T.,Ando, H.,Suzuki, T., et al. Identification of a primary target of Thalidomide teratogenicity. Science 327(5971), 1345-1350 (2010). 4.Lopez-Girona, A.,Mendy, D.,Miller, K., et al. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia 26(11), 2326-2335 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 258.2 |
| 分子式 | C13H10N2O4 |
| CAS号 | 50-35-1 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |