| 货号 | 16119-1mg |
| 描述 | Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides.1 The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer.2 ML351 is an inhibitor of human reticulocyte 15-LO-1 (IC50 = 200 nM) with >250-fold selectivity over the related enzymes 5-LO, platelet 12-LO, 15-LO-2, ovine COX-1, and human COX-2.3,4 ML351 was shown to be protective against oxidative glutamate toxicity in mouse neuronal HT-22 cells and significantly reduced infarct size in an in vivo mouse model for ischemic stroke.3,4 |
| 别名 | CID 664510; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Gaffney, B.J. Lipoxygenases: Structural principles and spectroscopy. Annual Reviews of Biophysical and Biomolecular Structure 25, 431-459 (1996). 2.Chanez, P.,Bonnans, C.,Chavis, C., et al. 15-Lipoxygenase. A janus enzyme? American Journal of Respiration, Cell, and Molecular Biology 27, 655-658 (2002). 3.Rai, G.,Joshi, N.,Perry, S., et al. Discovery of ML351, a potent and selective inhibitor of human 15-lipoxygenase-1. Probe Reports from the NIH Molecular Libraries Program (2010). 4.Rai, G.,Joshi, N.,Jung, J.E., et al. Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. Journal of Medicinal Chemistry 57(10), 4035-4048 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 249.3 |
| 分子式 | C15H11N3O |
| CAS号 | 847163-28-4 |
| 稳定性 | ≥ 2 years |
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