JW 480
货号：
10879-5mg 基本售价：
616.0 元 规格：
5 mg
产品信息
概述| 货号 | 10879-5mg |
| 描述 | The transmembrane enzyme KIAA1363 (also known as AADACL1) controls the production of the monoalkylglycerol ether (MAGE) class of neutral ether lipids (NELs) in cancer cells.1 Hyperactivity of this 2-acetyl MAGE hydrolase is associated with tumor cell migration, invasion, survival, and growth.2 JW 480 acts as a potent, selective inhibitor of KIAA1361 (IC50s = 20 nM in mouse brain membrane proteomes and 6-12 nM in human PC3 prostate cancer cell proteomes), showing little cross reactivity with hormone-sensitive lipase, acetylcholinesterase, or other serine hydrolases.2 JW 480 is active in vivo, reducing PC3 tumor xenograft growth in immune-deficient SCID mice at an oral dose of 80 mg/kg.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chiang, K.P.,Niessen, S.,Saghatelian, A., et al. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. Chemistry & Biology 13, 1041-1050 (2006).
2.Chang, J.W.,Nomura, D.K., and Cravatt, B.F. A potent a selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis. Chemistry & Biology 18(4), 476-484 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 333.4 |
| 分子式 | C22H23NO2 |
| CAS号 | 1354359-53-7 |
| 稳定性 | ≥ 2 years |
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