PF-04449913
货号：
9002936-1mg 基本售价：
560.0 元 规格：
1 mg
产品信息
概述| 货号 | 9002936-1mg |
| 描述 | PF-04449913 is an orally available Hedgehog pathway inhibitor that acts by binding Smoothened (Smo) and blocking signal transduction (IC50 = 5 nM).1 It has been shown to attenuate leukemia stem cell self-renewal and cell cycle progression in primary acute myeloid leukemia cells and in an in vivo Drosophila model.2,3 |
| 别名 | Glasdegib; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Munchhof, M.J.,Li, Q.,Shavnya, A., et al. Discovery of PF-04449913, a potent and orally bioavailable inhibitor of smoothened. ACS Med. Chem. Lett. 3(2), 106-111 (2011).
2.Fukushima, N.,Minami, Y.,Kakiuchi, S., et al. Small-molecule Hedgehog inhibitor attenuates the leukemia-initiation potential of acute myeloid leukemia cells. Cancer Sci. 107(10), 1422-1429 (2016).
3.Giordani, G.,Barraco, M.,Giangrande, A., et al. The human smoothened inhibitor PF-04449913 induces exit from quiescence and loss of multipotent Drosophila hematopoietic progenitor cells. Oncotarget 7(34), 55313-55327 (2016).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 374.4 |
| 分子式 | C21H22N6O |
| CAS号 | 1095173-27-5 |
| 稳定性 | ≥ 2 years |
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