| 货号 | 16976-1mg |
| 描述 | Casticin is a flavonol isolated from A. annua,V. trifolia, and V. agnus-castus that decreases proliferation in K562, HL-60, and Kasumi-1 leukemia cell lines (IC50s = 5.95, 4.82, and 15.56 µM, respectively).1 It blocks TGF-β/SMAD signaling in LX2 cells preventing activation, inhibiting proliferation, and inducing apoptosis of these hepatic stellate cells.2 In a mouse model of liver fibrosis, casticin (20 mg/kg) decreases TGF-β1 mRNA and phosphorylated SMAD (p-SMAD) levels. Casticin induces apoptosis in hepatocellular carcinoma (HCC) and breast cancer cells.3,4 It also downregulates Twist and prevents the epithelial-mesenchymal transition (EMT) in human HCC SMMC-7721 cells.5 |
| 别名 | Vitexicarpin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Shen, J.-K.,Du, H.-P.,Yang, M., et al. Casticin induces leukemic cell death through apoptosis and mitotic catastrophe. Ann. Hematol. 88(8), 743-752 (2009). 2.Zhou, L.,Dong, X.,Wang, L., et al. Casticin attenuates liver fibrosis and hepatic stellate cell activation by blocking TGF-β/Smad signaling pathway. Oncotarget (2017). 3.He, M.,Cao, X.C.,He, G.C., et al. Casticin inhibits epithelial-mesenchymal transition of liver cancer stem cells of the SMMC-7721 cell line through downregulating Twist. Oncol.Lett. 7(5), 1625-1631 (2014). 4.Liu, L.P.,Cao, X.C.,Liu, F., et al. Casticin induces breast cancer cell apoptosis by inhibiting the expression of forkhead box protein M1. Oncol.Lett. 7(5), 1711-1717 (2014). 5.Karim, Z.A.,Zhang, J.,Bangerjee, M., et al. IκB kinase phosphorylation of SNAP-23 controls platelet secretion. Blood 121(22), 4567-4574 (2013). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 374.3 |
| 分子式 | C19H18O8 |
| CAS号 | 479-91-4 |
| 稳定性 | ≥ 2 years |
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