Marinobufagenin
货号：
20798-500ug 基本售价：
546.0 元 规格：
500 ug
产品信息
概述| 货号 | 20798-500ug |
| 描述 | Marinobufagenin (MBG) is a bufadienolide steroid first isolated from toads of genus Bufo. It can also be excreted by mammalian cells, particularly kidney cells from hypertensive animals.1 MBG inhibits the ouabain-resistant α1Na+/K+ ATPase subunit (IC50 = 78 nM), impairing a major sodium pump of the kidneys, resulting in natriuresis and arterial hypertension.1,2 Serum and urine levels of MBG are also elevated after cardiac infarction, and a reduced form of MBG, marinobufotoxin, occurs in the plasma of patients with terminal renal failure.3,2 Through its effects on the α1Na+/K+ ATPase subunit, MBG has profound immediate and prolonged effects on kidney, heart, and vascular functions.2 |
| 别名 | Marinobufagin;MBG;NSC 234205; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Fedorova, O.V.,Kolodkin, N.I.,Agalakova, N.I., et al. Marinobufagenin, an endogenous alpha-1 sodium pump ligand, in hypertensive Dahl salt-sensitive rats. Hypertension 37(2 Pt 2), 462-466 (2001).
2.Schoner, W. and Scheiner-Bobis, G. Role of endogenous cardiotonic steroids in sodium homeostasis. Nephrol. Dial. Transplant. 23(9), 2723-2729 (2008).
3.Schoner, W. Endogenous cardiac glycosides, a new class of steroid hormones. Eur. J. Biochem. 269(10), 2440-2448 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 400.5 |
| 分子式 | C24H32O5 |
| CAS号 | 470-42-8 |
| 稳定性 | ≥ 2 years |
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