PHGDH-inactive
货号：
19717-1mg 基本售价：
546.0 元 规格：
1 mg
产品信息
概述| 货号 | 19717-1mg |
| 描述 | PHGDH-inactive is an inactive analog of the 3-phosphoglycerate dehydrogenase (PHGDH) inhibitors NCT-502 (Item No. 19716) and NCT-503 (Item No. 19718).1 Unlike the inhibitors, PHGDH-inactive does not inhibit PHGDH in vitro(IC50s = >57, 3.7, and 2.5 µM for PHGDH-inactive, NCT-502, and NCT-503, respectively), block serine synthesis in cells, or kill PHGDH-dependent cell lines.1 PHGDH-inactive is intended to serve as a negative control for NCT-502 and NCT-503. |
| 别名 | 3-Phosphoglycerate Dehydrogenase-inactive; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Pacold, M.E.,Brimacombe, K.R.,Chan, S.H., et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nature Chemical Biology 12(6), 452-458 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 327.5 |
| 分子式 | C17H21N5S |
| CAS号 | 1914971-16-6 |
| 稳定性 | ≥ 2 years |
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