| 货号 | 18720-10g |
| 描述 | Pentoxifylline is a methylxanthine derivative. It has been shown to have anti-inflammatory activity, inhibiting LPS-induced TNF-α production in isolated peripheral blood mononuclear cells (IC50 = 85 µM) and suppressing LPS-induced leukopenia in mice.1 Pentoxifylline weakly inhibits the generation of phosphatidic acid (IC50 = 500 µM) from LPS-activated lysophosphatidic acyl transferase (LPAAT), and weakly antagonizes A1 and A2 adenosine receptors.2,3 It also inhibits human acidic mammalian chitinase, human chitotriosidase, and chitinase B1 from Aspergillus fumigatus(IC50s = 49, 98, and 126 µM, respectively).4 |
| 别名 | NSC 637086;Oxpentifylline; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Cottam, H.B.,Shih, H.,Tehrani, L.R., et al. Substituted xanthines, pteridinediones, and related compounds as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor α. Journal of Medicinal Chemistry 39, 2-9 (1996). 2.Rice, G.C.,Brown, P.A.,Nelson, R.J., et al. Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid. Proceedings of the National Academy of Sciences of the United States of America 91, 3857-3861 (1994). 3.Schwabe, U.,Ukena, D. and Lohse, M.J. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors. Naunyn-Schmiedebergs Arch.Pharmacol. 330, 212-221 (1985). 4.Rao, F.V.,Andersen, O.A.,Vora, K.A., et al. Methylxanthine drugs are chitinase inhibitors: Investigation of inhibition and binding modes. Chemistry & Biology 12(9), 973-980 (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 278.3 |
| 分子式 | C13H18N4O3 |
| CAS号 | 1677687 |
| 稳定性 | ≥ 2 years |
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